About: MAD/MXI1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:DeprecatedClass, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MAD/MXI1
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • MAD/MXI1
OLD_PARENT
  • Transcription Corepressor
OLD_KIND
  • Protein_Kind
Concept_Status
  • Retired_Concept
FULL_SYN
  • MAD/MXI1PTNCI
DEFINITION
  • MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins. MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity; MYC homodimers are inactive. MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for DNA binding sites, and recruit SIN3 proteins and their associated co-repressors. (from OMIM 600021, 600020, and NCI)NCI
DesignNote
  • See 'MAX Interacting Protein 1' or 'MAX Dimerization Protein 1'
code
  • C19893
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