About: Prostaglandin G/H Synthase 1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prostaglandin G/H Synthase 1
equivalentClass
OMIM_Number
  • 176805
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Prostaglandin G/H Synthase 1
UMLS_CUI
  • C0389003
Legacy_Concept_Name
  • Prostaglandin-Endoperoxide_Synthase-1
FULL_SYN
  • COXSYNCI
  • EC 1.14.99.1SYNCI
  • PGH SynthaseSYNCI
  • PGH Synthase 1SYNCI
  • Prostaglandin G/H Synthase and CyclooxygenaseSYNCI
  • Prostaglandin H2 SynthaseSYNCI
  • Fatty Acid CyclooxygenaseSYNCI
  • Prostaglandin-Endoperoxide SynthaseSYNCI
  • CyclooxygenaseSYNCI
  • COX1SYNCI
  • PHS1SYNCI
  • COX3SYNCI
  • PTGSSYNCI
  • Prostaglandin H2 Synthase 1SYNCI
  • Cyclooxygenase 3SYNCI
  • Cyclooxygenase-1SYNCI
  • Prostaglandin-Endoperoxide Synthase 1SYNCI
  • PHS 1SYNCI
  • COX-1SYNCI
  • PTGS1SYNCI
  • Cyclo-Oxygenase-1SYNCI
  • Prostaglandin G/H Synthase 1PTNCI
  • PGHS-1SYNCI
Swiss_Prot
  • P23219
DEFINITION
  • Prostaglandin G/H synthase 1 (599 aa, ~69 kDa) is encoded by the human PTGS1 gene. This protein plays a role in vasoconstriction, blood pressure homeostasis and prostaglandin metabolism.NCI
DesignNote
  • COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and mitogens, hence it is likely to play a role in inflammatory diseases such as rheumatoid arthritis. It contains one EGF-like domain. Both isoforms have the same affinity to convert arachidonic acid to prostaglandin. COX-1. Both forms of COX proteins are membrane associated heme proteins containing cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin.
code
  • C19705
sameAs
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