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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rebimastat
equivalentClass
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Rebimastat
NSC_Code
  • 713763
UMLS_CUI
  • C0935902
CAS_Registry
  • 259188-38-0
In_Clinical_Trial_For
  • Prostate cancer
FDA_UNII_Code
  • 1B47R6ZX4K
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called matrix metalloproteinase inhibitors (MMPIs).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38088
PDQ_Closed_Trial_Search_ID
  • 38088
Chemical_Formula
  • C23H41N5O5S
Legacy_Concept_Name
  • BMS-275291
FULL_SYN
  • BMS-275291PTDCP50521
  • N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamideSNNCI
  • D2163CNNCI
  • REBIMASTATPTFDA1B47R6ZX4K
  • BMS-275291PTNCI-GLOSSCDR0000044972
  • BMS-275291CNNCI
  • RebimastatPTNCI
DEFINITION
  • A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.NCI
code
  • C1875
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