About: FPS-FES Oncoprotein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • FPS-FES Oncoprotein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • FPS-FES Oncoprotein
UMLS_CUI
  • C0919518
Legacy_Concept_Name
  • FPS-FES_Protein
FULL_SYN
  • FPS-FES OncoproteinPTNCI
DEFINITION
  • Human FPS-FES Protein is a product of a mutated variant (Oncogene FPS-FES) of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. FPS-FES Protein disrupts normal cell function.NCI
code
  • C18578
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