About: Oncogene MYCN     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oncogene MYCN
equivalentClass
OMIM_Number
  • 164840
GenBank_Accession_Number
  • NM_005378
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Oncogene MYCN
NCI_META_CUI
  • CL414356
Legacy_Concept_Name
  • Oncogene_NMYC
FULL_SYN
  • Oncogene MYCNPTNCI
  • Oncogene NMYCSYNCI
  • Neuroblastoma MYC OncogeneSYNCI
  • N-MYCSYNCI
  • v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian)SYNCI
DEFINITION
  • Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.NCI
code
  • C18444
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