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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • BMS-184476
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • BMS-184476
UMLS_CUI
  • C0796479
CAS_Registry
  • 160237-25-2
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43331
PDQ_Closed_Trial_Search_ID
  • 43331
Legacy_Concept_Name
  • BMS-184476
FULL_SYN
  • 7-O-[(Methylthio)methyl]paclitaxelSNNCI
  • beta-(Benzoylamino)-a-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1HSNNCI
  • beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1HPTDCP50582
  • BMS-184476PTNCI-GLOSSCDR0000046176
  • BMS-184476CNNCI
  • BMS-184476PTNCI
DEFINITION
  • A 7-methylthiomethyl ether derivative of paclitaxel with antineoplastic activity. BMS-184476 binds to and stabilizes the resulting microtubules, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and apoptosis. (NCI)NCI
code
  • C1843
http://linked.open...y/mesh/hasConcept
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