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AttributesValues
rdf:type
rdfs:label
  • Lepirudin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Lepirudin
UMLS_CUI
  • C0772394
CAS_Registry
  • 138068-37-8
FDA_UNII_Code
  • Y43GF64R34
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that inhibits blood clotting. It is being studied in cancer treatment.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43356
PDQ_Closed_Trial_Search_ID
  • 43356
Chemical_Formula
  • C287H440N80O111S6
Legacy_Concept_Name
  • Lepirudin
FULL_SYN
  • LEPIRUDINPTFDAY43GF64R34
  • Recombinant HirudinSYNCI
  • RefludanBRNCI
  • LepirudinPTNCI
  • lepirudinPTNCI-GLOSSCDR0000046191
DEFINITION
  • A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.NCI
code
  • C1839
sameAs
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