About: Fc-Gamma Receptor II     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fc-Gamma Receptor II
rdfs:subClassOf
Semantic_Type
  • Receptor
  • Immunologic Factor
Preferred_Name
  • Fc-Gamma Receptor II
UMLS_CUI
  • C0796385
Legacy_Concept_Name
  • Fc-Gamma_Receptor-II
FULL_SYN
  • Fc-Gamma Receptor IIPTNCI
DEFINITION
  • Generally expressed in monocytes, macrophages, polymorphonuclear cells, NK cells, T- and B-lymphocytes, and platelets, Fc-Gamma Receptors II are type I cell surface membrane protein low affinity receptors for aggregated IgG Fc region with 2 extracellular IgC2 domains and cytoplasmic ITIM or ITAM motifs involved in cell activation upon receptor aggregation. IgG binding initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. (NCI)NCI
code
  • C18308
is rdf:first of
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