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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Raltitrexed
equivalentClass
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Raltitrexed
NSC_Code
  • 639186
UMLS_CUI
  • C0677667
CAS_Registry
  • 112887-68-0
FDA_UNII_Code
  • FCB9EGG971
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42625
PDQ_Closed_Trial_Search_ID
  • 42625
Chemical_Formula
  • C21H22N4O6S
Legacy_Concept_Name
  • Raltitrexed
FULL_SYN
  • RaltitrexedPTNCI
  • raltitrexedPTNCI-GLOSSCDR0000045528
  • D1694CNNCI
  • N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic AcidSNNCI
  • ZD1694CNNCI
  • N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic AcidSNNCI
  • TomudexBRNCI
  • ICI D1694PTNCI-GLOSSCDR0000044456
  • ICI D1694CNNCI
  • RALTITREXEDPTFDAFCB9EGG971
DEFINITION
  • A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)NCI
code
  • C1804
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