About: Cisplatin-E Therapeutic Implant     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Cisplatin-E Therapeutic Implant
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cisplatin-E Therapeutic Implant
UMLS_CUI
  • C0677669
PDQ_Open_Trial_Search_ID
  • 42697
PDQ_Closed_Trial_Search_ID
  • 42697
Legacy_Concept_Name
  • Cisplatin-E_Therapeutic_Implant
FULL_SYN
  • CDDP/epi gelSYNCI
  • Cisplatin/Epinephrine GelSYNCI
  • CEGABNCI
  • CDDP-e therapeutic implantSYNCI
  • MP 5010 Therapeutic ImplantSYNCI
  • Intradose MPI-5010SYNCI
  • MPI 5010SYNCI
  • CDDP/epiSYNCI
  • Cisplatin-E Therapeutic ImplantPTNCI
  • IntradoseSYNCI
  • MP 5010 TISYNCI
  • Cisplatin-EpinephrineSYNCI
DEFINITION
  • An injectable collagen matrix gel containing the inorganic platinum agent cisplatin and the sympathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, cisplatin alkylates guanine nucleosides in DNA, and causes DNA-DNA or DNA-protein cross-linkages, thereby preventing DNA replication and resulting in tumor cell growth inhibition and apoptosis. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of cisplatin into tumor tissue and reduce dispersion into the surrounding tissues. Intratumoral injection of cisplatin-E therapeutic implant may increase local chemotherapeutic efficacy compared to the systemic administration of these agents while reducing systemic toxicity.NCI
code
  • C17879
is someValuesFrom of
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