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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Omapatrilat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Omapatrilat
UMLS_CUI
  • C0663645
CAS_Registry
  • 167305-00-2
FDA_UNII_Code
  • 36NLI90E7T
Contributing_Source
  • FDA
Chemical_Formula
  • C19H24N2O4S2
Legacy_Concept_Name
  • Omapatrilat
FULL_SYN
  • OmapatrilatPTNCI
  • BMS-186716-01CNNCI
  • (4S,7S,10aS)-Octahydro-4-((S)-.Alpha.-Mercaptohydrocinnamamido)-5-Oxo-7H-Pyrido(2,1-B)(1,3)Thiazepine-7-Carboxylic AcidSNNCI
  • OmapatrilateSYNCI
  • VanlevBRNCI
  • OMAPATRILATPTFDA36NLI90E7T
  • BMS-186716CNNCI
DEFINITION
  • A vasopeptidase inhibitor with antihypertensive activity. Omapatrilat exerts its effect by inhibiting angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP). ACE inhibition results in inhibition of the renin-angiotensin-aldosterone system thereby leading to the reduction of vasoconstriction. Inhibition of NEP leads to the inhibition of hydrolyzation of a number of endogenous vasoactive peptides, such as bradykinin and substance P and as NEP is the principal enzyme degrading natriuretic peptides, NEP inhibition also results in an increase in natriuretic peptidase circulation. Ultimately both effects result in blood vessel relaxation.NCI
code
  • C1782
sameAs
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