About: Topoisomerase II Beta     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topoisomerase II Beta
equivalentClass
OMIM_Number
  • 126431
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Topoisomerase II Beta
UMLS_CUI
  • C1504636
Legacy_Concept_Name
  • Topoisomerase-II_Beta
FULL_SYN
  • Topoisomerase (DNA) II Beta 180kDaSYNCI
  • Topo II BetaSYNCI
  • DNA Topoisomerase II, Beta IsozymeSYNCI
  • Topoisomerase (DNA) II Beta (180kD)SYNCI
  • DNA Topoisomerase II, 180 kDSYNCI
  • TOP2BSYNCI
  • Topoisomerase, DNA, II, BetaSYNCI
  • Topoisomerase II BetaPTNCI
Swiss_Prot
  • Q02880
DEFINITION
  • Encoded by human TOP2B Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa) control DNA topology. TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
  • Both topo II alpha and beta isoforms exhibit ATP-dependent strand passage activity, but they differ in several key aspects. The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement. The beta isoform has a molecular weight of 180 KD, and is immunologically distinct as well as exhibits different SV8 proteolytic cleavage pattern from alpha isoform.NCI
code
  • C17802
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
Faceted Search & Find service v1.16.116 as of Feb 22 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 82 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software