About: Insulin-Like Growth Factor-Binding Protein 6     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Insulin-Like Growth Factor-Binding Protein 6
equivalentClass
OMIM_Number
  • 146735
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Insulin-Like Growth Factor-Binding Protein 6
UMLS_CUI
  • C0169975
Legacy_Concept_Name
  • Insulin-Like_Growth_Factor-Binding_Protein-6
FULL_SYN
  • Insulin-Like Growth Factor Binding Protein 6SYNCI
  • Insulin-Like Growth Factor-Binding Protein 6PTNCI
  • IGFBP6SYNCI
  • IGFBP-6SYNCI
  • IGF Binding Protein 6SYNCI
Swiss_Prot
  • P24592
DEFINITION
  • Insulin-like growth factor binding protein 6 (240 aa, 25 kD) is a cellular division process protein that is encoded by the human IGFBP6 gene and has a role in negative regulation of cell proliferation.NCI
DesignNote
  • IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI)
code
  • C17587
sameAs
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