About: AP-2 Family Transcription Factor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • AP-2 Family Transcription Factor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • AP-2 Family Transcription Factor
UMLS_CUI
  • C1332097
Legacy_Concept_Name
  • AP-2_Family_Transcription_Factor
FULL_SYN
  • Activator Protein-2 Family Transcription FactorSYNCI
  • AP-2 Family ProteinSYNCI
  • AP-2 Family Transcription FactorPTNCI
DEFINITION
  • Activator Protein 2. Originally identified as a cellular transcription factor that binds the enhancer region of SV40. It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma. AP-2 is developmentally regulated and inducible by RET.NCI
DesignNote
  • AP-2 family transcription factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. (UniProt)
code
  • C17545
is someValuesFrom of
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