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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • FAT Protein
equivalentClass
OMIM_Number
  • 600976
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • FAT Protein
UMLS_CUI
  • C1435181
Legacy_Concept_Name
  • FAT_Protein
FULL_SYN
  • FATSYNCI
  • FAT ProteinPTNCI
  • Cadherin-Related Tumor SuppressorSYNCI
  • Cadherin ME5SYNCI
  • Cadherin Family Member 7SYNCI
Swiss_Prot
  • Q14517
DEFINITION
  • The transmembrane FAT protein contains 34 cadherin repeats and a number of other motifs. FAT may be involved in contact-dependent cell interactions important in regulating growth. FAT mRNA is present in many epithelia and in some endothelial and smooth muscle cells. (from OMIM 600976 and NCI)NCI
  • The gene encoding this protein is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. This protein is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. (from LocusLink)NCI
code
  • C17492
http://linked.open...y/mesh/hasConcept
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