About: E-Selectin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • E-Selectin
equivalentClass
OMIM_Number
  • 131210
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • E-Selectin
UMLS_CUI
  • C0115305
ALT_DEFINITION
  • Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.MSH2001
Legacy_Concept_Name
  • E-Selectin
FULL_SYN
  • Cell Adhesion Molecule E-SelectinSYNCI
  • Leukocyte Endothelial Cell Adhesion Molecule 2SYNCI
  • ELAMABNCI
  • ESELABNCI
  • SELEABNCI
  • CD62EABNCI
  • ELAM1ABNCI
  • LECAM2ABNCI
  • Endothelial Adhesion Molecule 1SYNCI
  • Endothelial Leukocyte Adhesion Molecule 1SYNCI
  • E-SelectinPTNCI
Swiss_Prot
  • P16581
DEFINITION
  • Encoded by human SELE Gene (Selectin Family), 610-aa 66.5-kD E-Selectin precursor is a cytokine-induced endothelia type I membrane protein with features homologous to LYAM1: a C-type lectin domain, an EGF-like domain, six cysteine-containing SCR (sushi) domains. Likely having an evolutionary history with LYAM1, GRMP, and complement binding proteins, ELAM1 mediates cell adhesion binding of endothelial cells to leukocytes, such as Neutrophils, during inflammatory responses. ELAM1 recognizes glycolipid polylactosamine derivatives and may be involved in the pathogenesis of atherosclerosis. An aa149 polymorphism is associated with higher risk of coronary artery disease and ELAM1 is a diagnostic indicator of glaucoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
  • E-Selectin is expressed by cytokine-stimulated endothelial cells and is thought responsible for accumulation of neutrophils, monocytes, and memory T-cells at sites of inflammation. Neutrophil accumulation at sites of inflammation is mediated by cell adhesion molecules including the CD18 integrins on leukocytes and the selectins (P- and E-selectin on endothelium and L-selectin on leukocytes). E-Selectin exhibits homologous structural features to L-selectin, including lectin- and EGF-like domains followed by SCR domains. E-Selectin recognizes Lewis X family- or Lewis A family-related sialylated carbohydrate groups. (from OMIM 131210 and NCI)NCI
  • Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.NCI
code
  • C17491
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software