About: FOS Oncoprotein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • FOS Oncoprotein
equivalentClass
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • FOS Oncoprotein
UMLS_CUI
  • C0085301
ALT_DEFINITION
  • Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55 kD protein and the FBR-MSV v-fos gene encodes a p75 kD fusion protein.MSH2001
Legacy_Concept_Name
  • FOS_Oncoprotein
FULL_SYN
  • Cellular Oncogene c-FOSSYNCI
  • G0S7 ProteinSYNCI
  • FOS OncoproteinPTNCI
Swiss_Prot
  • P01100
DEFINITION
  • c-FOS protein is a transcription factor critical in regulating the development of the skeleton. c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family. Each protein contains a bZIP domain and a leucine zipper domain. FOS oncoproteins derive from mutated FOS genes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein. (from OMIM 164810 and NCI)NCI
code
  • C17439
sameAs
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