About: Proto-Oncogene c-Fos     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Proto-Oncogene c-Fos
equivalentClass
OMIM_Number
  • 164810
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Proto-Oncogene c-Fos
UMLS_CUI
  • C0596588
Legacy_Concept_Name
  • FOS_Protein
FULL_SYN
  • G0/G1 Switch Regulatory Protein 7SYNCI
  • FOS ProteinSYNCI
  • c-fos ProteinSYNCI
  • FOSSYNCI
  • FBJ Murine Osteosarcoma Viral Oncogene HomologSYNCI
  • Proto-Oncogene c-FosPTNCI
  • Cellular Oncogene FosSYNCI
Swiss_Prot
  • P01100
DEFINITION
  • Proto-oncogene c-Fos (380 aa, ~41 kDa) is encoded by the human FOS gene. This protein is involved in transcriptional regulation, DNA binding and signal transduction.NCI
DesignNote
  • FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members. Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes. (from OMIM 164810)
code
  • C17438
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