About: CD31 Antigen     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CD31 Antigen
equivalentClass
OMIM_Number
  • 173445
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • CD31 Antigen
UMLS_CUI
  • C0081939
Legacy_Concept_Name
  • CD31_Antigen
FULL_SYN
  • Platelet Endothelial Cell Adhesion MoleculeSYNCI
  • CD31 AntigenPTNCI
  • GPIIA'SYNCI
  • PECAM1SYNCI
  • PECAM-1SYNCI
  • EndoCAMSYNCI
Swiss_Prot
  • P16284
DEFINITION
  • CD31 antigen (738 aa, 83 kD) is a cell communication protein that is encoded by the human PECAM1 gene and has a role in cell recognition and signal transduction.NCI
DesignNote
  • Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
  • A cell adhesion molecule present on virtually all monocytes, platelets, and granulocytes, CD31 is highly expressed on endothelial cells and concentrated at the junctions between them. An integral membrane glycoprotein that contains six extracellular Ig-like domains, one transmembrane domain, and a cytoplasmic domain, CD31 is most similar to the CAM subgroup of the Ig superfamily. PECAM1 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members mediate cell adhesion, or antigen recognition, T-cell receptors, and MHC molecules. A subgroup contains one or more cytoplasmic ITIM motifs. PECAM1 has six ITIMs and may serve as a negative regulator of platelet-collagen interactions that may limit growth of platelet thrombi on collagen surfaces.
code
  • C17402
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
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