About: p21 K-Ras Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • p21 K-Ras Protein
equivalentClass
OMIM_Number
  • 190070
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • p21 K-Ras Protein
UMLS_CUI
  • C0079973
Legacy_Concept_Name
  • p21_K-Ras_Protein
FULL_SYN
  • KRASSYNCI
  • KRAS2SYNCI
  • K-Ras 2ASYNCI
  • K-Ras-2 p21SYNCI
  • K-Ras-2 ProteinSYNCI
  • c-K-Ras ProteinSYNCI
  • p21 K-Ras ProteinPTNCI
  • K-Ras p21 ProteinSYNCI
  • Ki-RasSYNCI
  • c-K-RasSYNCI
Swiss_Prot
  • P01116
DEFINITION
  • p21 K-RAS protein is encoded by the K-RAS gene. Two KRAS isoforms are produced by alternative splicing. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form. RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein. This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors. KRAS is involved in malignancy much more often than is HRAS. (from OMIM 190070, SWISS-PROT P01116, P01118, and NCI)NCI
DesignNote
  • 2 isoforms made by alternate splicing
code
  • C17383
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