About: Topoisomerase III     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topoisomerase III
rdfs:subClassOf
Semantic_Type
  • Enzyme
Preferred_Name
  • Topoisomerase III
UMLS_CUI
  • C0114645
Legacy_Concept_Name
  • Topoisomerase-III
FULL_SYN
  • Topoisomerase IIIPTNCI
  • Topo IIISYNCI
  • DNA Topoisomerase IIISYNCI
DEFINITION
  • Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA). Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products.NCI
code
  • C17340
http://linked.open...y/mesh/hasConcept
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