About: Haptoglobin-Related Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Haptoglobin-Related Protein
rdfs:subClassOf
OMIM_Number
  • 140210
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Haptoglobin-Related Protein
UMLS_CUI
  • C0062120
Legacy_Concept_Name
  • Haptoglobin-Related_Protein
FULL_SYN
  • HPRSYNCI
  • Haptoglobin-Related ProteinPTNCI
Swiss_Prot
  • P00739
DEFINITION
  • Haptoglobin-related protein (348 aa, ~39 kDa) is encoded by the human HPR gene. This protein plays a role in hemoglobin binding.NCI
DesignNote
  • Although homologous to serine proteases, haptoglobin-related protein is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt)
  • Haptoglobin-related protein (trypanosome lytic factor) confers human resistance to Trypanosome brucei. HPR or HPR-like epitopes are expressed in human breast carcinoma. Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor.
code
  • C17299
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