About: Tumor Necrosis Factor Receptor Superfamily Member 5     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tumor Necrosis Factor Receptor Superfamily Member 5
equivalentClass
OMIM_Number
  • 109535
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Tumor Necrosis Factor Receptor Superfamily Member 5
UMLS_CUI
  • C0054959
ALT_DEFINITION
  • 50 kD glycoprotein expressed on all B cells; plays an important role in B cell development and activation.CSP2000
Legacy_Concept_Name
  • CD40L_Receptor
FULL_SYN
  • CD40 AntigenSYNCI
  • CD40L ReceptorSYNCI
  • CD40SYNCI
  • TNFRSF5SYNCI
  • CD40 Type II IsoformSYNCI
  • B Cell-Associated Molecule CD40SYNCI
  • Tumor Necrosis Factor Receptor Superfamily Member 5PTNCI
  • Nerve Growth Factor Receptor-Related B-Lymphocyte Activation MoleculeSYNCI
Swiss_Prot
  • P25942
DEFINITION
  • Tumor necrosis factor receptor superfamily member 5 (277 aa, 31 kD) is a cell fate protein that is encoded by the human CD40 gene and has roles in inflammatory response, B-cell proliferation and apoptosis.NCI
DesignNote
  • Related to NGFR, TNFR-alpha, and CD27, CD40 is a 50 kD glycophosphoprotein homodimer expressed on mature B-cells, but not on plasma cells, that plays an important role in B-cell development and activation. These CD40 homologies imply that its ligand may be a soluble factor and that CD40 is a member of the cytokine receptor family. CD40/CD40-ligand interactions play a critical role in the activation of humoral and cell-mediated immune responses. CD40-dependent activation of B-cells is important for generation of memory B-cells within germinal centers. (OMIM)
code
  • C17281
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