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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Perifosine
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Perifosine
NSC_Code
  • 639966
UMLS_CUI
  • C0538860
CAS_Registry
  • 157716-52-4
In_Clinical_Trial_For
  • Male Breast cancer; Prostate cancer
FDA_UNII_Code
  • 2GWV496552
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylphospholipids.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43408
PDQ_Closed_Trial_Search_ID
  • 43408
Chemical_Formula
  • C25H52NO4P
Legacy_Concept_Name
  • Perifosine
FULL_SYN
  • 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner SaltSNNCI
  • perifosinePTNCI-GLOSSCDR0000046203
  • 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner SaltPTDCP50512
  • OctadecylphosphopiperidineSYNCI
  • D21266CNNCI
  • Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphateSNNCI
  • PERIFOSINEPTFDA2GWV496552
  • PerifosineSYDTPNSC0639966
  • PerifosinePTNCI
DEFINITION
  • An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. (NCI04)NCI
code
  • C1727
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