About: Urokinase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Urokinase
equivalentClass
OMIM_Number
  • 191840
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Urokinase
UMLS_CUI
  • C0042071
ALT_DEFINITION
  • An enzyme that is made in the kidney and found in the urine. A form of this enzyme is made in the laboratory and used to dissolve blood clots or to prevent them from forming.NCI-GLOSS
Legacy_Concept_Name
  • Urokinase
FULL_SYN
  • PLAUSYNCI
  • Urokinase-Type Plasminogen ActivatorSYNCI
  • Urinary Plasminogen ActivatorSYNCI
  • Urokinase Plasminogen ActivatorSYNCI
  • Plasminogen Activator, UrokinaseSYNCI
  • uPAPTNCI-GLOSSCDR0000658873
  • U-Plasminogen ActivatorSYNCI
  • urokinase-plasminogen activatorPTNCI-GLOSSCDR0000658871
  • uPAABNCI
  • u-PASYNCI
  • Plasminogen Activator, UrinarySYNCI
  • UrokinasePTNCI
  • urokinasePTNCI-GLOSSCDR0000045245
  • u-plasminogen activatorPTNCI-GLOSSCDR0000658872
Swiss_Prot
  • P00749
DEFINITION
  • Encoded by human PLAU Gene (Peptidase S1 Family), 431-aa 48.5-kD single-chain Urokinase precursor contains a kringle and an EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)NCI
code
  • C17242
sameAs
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