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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Irofulven
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Irofulven
NSC_Code
  • 683863
UMLS_CUI
  • C0532362
CAS_Registry
  • 158440-71-2
In_Clinical_Trial_For
  • Gastric cancer; Ovarian epithelial or peritoneal cancer
FDA_UNII_Code
  • 6B799IH05A
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. Irofulven attaches to the cell's DNA and may block cancer cell growth. It is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43097
PDQ_Closed_Trial_Search_ID
  • 43097
Chemical_Formula
  • C15H18O3
Legacy_Concept_Name
  • Irofulven
FULL_SYN
  • LAMBABNCI
  • HMAFSYDTPNSC0683863
  • IrofulvenPTDCP50542
  • 6-HydroxymethylacylfulveneSYDTPNSC0683863
  • HydroxymethylacylfulveneSYNCI
  • (R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-oneSNNCI
  • 6-HydroxymethylacylfulveneSYNCI
  • 6-hydroxymethylacylfulvenePTNCI-GLOSSCDR0000043967
  • IROFULVENPTFDA6B799IH05A
  • MGI 114CNNCI
  • MGI-114CNNCI
  • IrofulvenPTNCI
  • irofulvenPTNCI-GLOSSCDR0000046045
DEFINITION
  • A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents. (NCI04)NCI
code
  • C1717
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