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AttributesValues
rdf:type
rdfs:label
  • RAS Family Oncogene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • RAS Family Oncogene
UMLS_CUI
  • C0034678
ALT_DEFINITION
  • Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.MSH2001
Legacy_Concept_Name
  • RAS_Family_Oncogene
FULL_SYN
  • RAS OncogeneSYNCI
  • Oncogene RASSYNCI
  • RASSYNCI
  • Retrovirus Associated Sequence OncogeneSYNCI
  • RAS Family OncogenePTNCI
DEFINITION
  • Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. Critically involved in cell activation and replication in many cell types, and disruption of its regulation can lead to uncontrolled growth.NCI
code
  • C17061
http://linked.open...y/mesh/hasConcept
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