About: Nelarabine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Nelarabine
rdfs:subClassOf	Purine Antagonist nodeID://b696199 nodeID://b696200 nodeID://b696201
Has_Target	DNA
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Nelarabine
NSC_Code	686673
UMLS_CUI	C0907349
CAS_Registry	121032-29-9
Accepted_Therapeutic_Use_For	T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma
In_Clinical_Trial_For	T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma
FDA_UNII_Code	60158CV180
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43260
PDQ_Closed_Trial_Search_ID	43260
Chemical_Formula	C11H15N5O5
Legacy_Concept_Name	Nelarabine
CHEBI_ID	CHEBI:63612
FULL_SYN	nelarabinePTNCI-GLOSSCDR0000367460 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purineSNNCI 2-Amino, 6-Methoxypurine ArabinosideSNNCI 2-Amino-6-methoxypurine arabinosideSYDTPNSC0686673 Compound 506U78SYNCI 506U78PTNCI-GLOSSCDR0000046136 506U78CNNCI ArranonPTNCI-GLOSSCDR0000507537 ArranonBRNCI NELARABINEPTFDA60158CV180 GW506U78CNNCI NelarabinePTNCI
DEFINITION	An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)NCI
code	C1704
sameAs	NELARABINE NELARABINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0359430
is someValuesFrom of	nodeID://b647173 nodeID://b692558 nodeID://b725309 nodeID://b725314
is sameAs of	NELARABINE NELARABINE NELARABINE

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