About: Tipifarnib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tipifarnib
rdfs:subClassOf	Farnesyl Transferase Inhibitor nodeID://b719849 nodeID://b719850 nodeID://b719851 nodeID://b719852 nodeID://b719853 nodeID://b719854 nodeID://b719855
Has_Target	Farnesyl Protein Transferase
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Tipifarnib
NSC_Code	702818
UMLS_CUI	C1176289
CAS_Registry	192185-72-1
FDA_UNII_Code	MAT637500A
Contributing_Source	FDA
ALT_DEFINITION	A substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42626
PDQ_Closed_Trial_Search_ID	42626
Chemical_Formula	C27H22Cl2N4O
Legacy_Concept_Name	Tipifarnib
FULL_SYN	tipifarnibPTNCI-GLOSSCDR0000257898 TipifarnibPTDCP20470 R115777SYNCI-GLOSSCDR0000045529 R115777CNNCI TIPIFARNIBPTFDAMAT637500A (+)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinoneSNNCI ZarnestraBRNCI ZarnestraPTNCI-GLOSSCDR0000485224 TipifarnibPTNCI
DEFINITION	A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)NCI
code	C1703
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0355462
is someValuesFrom of	nodeID://b656631 nodeID://b656656 nodeID://b660377 nodeID://b663202 nodeID://b676708 nodeID://b676718 nodeID://b686669 nodeID://b705948 nodeID://b705951 nodeID://b718889 nodeID://b719856 nodeID://b719859

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