About: Plitidepsin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Plitidepsin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Plitidepsin
NSC_Code
  • 638719
UMLS_CUI
  • C0388638
CAS_Registry
  • 137219-37-5
In_Clinical_Trial_For
  • Lymphomas; melanomas; neuroendocrine tumors.
FDA_UNII_Code
  • Y76ID234HW
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 460052
PDQ_Closed_Trial_Search_ID
  • 460052
Legacy_Concept_Name
  • Aplidine
FULL_SYN
  • PlitidepsinPTNCI
  • DDBABNCI
  • Dehydrodemnin BSYNCI
  • APLDABNCI
  • Dehydrodidemnin BSYNCI
  • AplidinBRNCI
  • aplidinePTNCI-GLOSSCDR0000046693
  • AplidineSYNCI
  • PLITIDEPSINPTFDAY76ID234HW
  • N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin ASNNCI
  • AplidinePTDCP50576
DEFINITION
  • A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.NCI
code
  • C1689
http://linked.open...y/mesh/hasConcept
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