About: Alemtuzumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alemtuzumab
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Alemtuzumab
NSC_Code
  • 715969
UMLS_CUI
  • C0383429
CAS_Registry
  • 216503-57-0
Accepted_Therapeutic_Use_For
  • Chronic Lymphocytic Leukemia (CLL)
FDA_UNII_Code
  • 3A189DH42V
Contributing_Source
  • FDA
ALT_DEFINITION
  • A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37783
PDQ_Closed_Trial_Search_ID
  • 37783
Legacy_Concept_Name
  • Alemtuzumab
FULL_SYN
  • Campath-1HPTNCI-GLOSSCDR0000044002
  • AlemtuzumabPTNCI
  • alemtuzumabPTNCI-GLOSSCDR0000044851
  • LDP-03CNNCI
  • Anti-CD52 Monoclonal AntibodySYNCI
  • CampathBRNCI
  • Monoclonal Antibody Campath-1HSYNCI
  • ALEMTUZUMABPTFDA3A189DH42V
  • Campath-1HSYNCI
  • MabCampathFBNCI
DEFINITION
  • A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein, CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. (NCI04)NCI
code
  • C1681
sameAs
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