About: Recombinant Interleukin-18     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Interleukin-18
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Interleukin-18
UMLS_CUI
  • C1527127
PDQ_Open_Trial_Search_ID
  • 386168
PDQ_Closed_Trial_Search_ID
  • 386168
Legacy_Concept_Name
  • Therapeutic_Interleukin-18
FULL_SYN
  • Interferon-Gamma-Inducing FactorSYNCI
  • IFN-Gamma-Inducing FactorSYNCI
  • Interleukin-18SYNCI
  • Recombinant Interleukin-18PTNCI
  • IL-18ABNCI
DEFINITION
  • A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL). As a potential immunotherapeutic agent, IL-18 displays antitumor effects in vitro and in animal models. (NCI04)NCI
code
  • C1680
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