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AttributesValues
rdf:type
rdfs:label
  • Ibandronate Sodium
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Ibandronate Sodium
UMLS_CUI
  • C0772244
CAS_Registry
  • 138926-19-9
Accepted_Therapeutic_Use_For
  • Osteoporosis, treatment and prevention
In_Clinical_Trial_For
  • Localized metastatic bone pain
FDA_UNII_Code
  • J12U072QL0
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 365963
PDQ_Closed_Trial_Search_ID
  • 365963
Chemical_Formula
  • C9H22NO7P2.Na.H2O
Legacy_Concept_Name
  • Ibandronate
FULL_SYN
  • ibandronatePTNCI-GLOSSCDR0000377709
  • Ibandronate SodiumPTDCP20612
  • BonivaBRNCI
  • Ibandronate SodiumPTNCI
  • IBANDRONATE SODIUMPTFDAJ12U072QL0
  • BondronateFBNCI
DEFINITION
  • The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.NCI
code
  • C1670
sameAs
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