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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cadherin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Cadherin
UMLS_CUI
  • C0006631
ALT_DEFINITION
  • A group of functionally related glycoproteins responsible for the calcium-dependent cell-to-cell adhesion mechanism. They are divided into subclasses E-, P-, and N-cadherins, which are distinct in immunological specificity and tissue distribution. They promote cell adhesion via a homophilic mechanism. These compounds play a role in the construction of tissues and of the whole animal body.MSH2001
  • family of cell surface glycoproteins, first identified in vertebrates, that mediate calcium dependent, homophilic cell adhesion and thereby control tissue morphogenesis.CSP2000
Legacy_Concept_Name
  • Cadherin
FULL_SYN
  • CadherinPTNCI
DEFINITION
  • The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets.NCI
code
  • C16373
sameAs
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