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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bexarotene
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Bexarotene
UMLS_CUI
  • C0765273
CAS_Registry
  • 153559-49-0
Accepted_Therapeutic_Use_For
  • Oral or topical treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL).
In_Clinical_Trial_For
  • Mycosis fungoides; cutaneous T-cell lymphoma; chemoprevention for women at high genetic risk for breast cancer
FDA_UNII_Code
  • A61RXM4375
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat skin problems caused by cutaneous T-cell lymphoma that have not gotten better after other treatment. It is also being studied in the treatment of other types of cancer. Bexarotene is a type of retinoid.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42117
PDQ_Closed_Trial_Search_ID
  • 42117
Chemical_Formula
  • C24H28O2
Legacy_Concept_Name
  • Bexarotene
CHEBI_ID
  • CHEBI:50859
FULL_SYN
  • bexarotenePTNCI-GLOSSCDR0000045423
  • BexarotenePTDCP09151
  • 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic AcidSNNCI
  • 3-methyl TTNEBSYNCI
  • LGD1069PTNCI-GLOSSCDR0000044482
  • LGD1069CNNCI
  • BEXAROTENEPTFDAA61RXM4375
  • TargretinBRNCI
  • TargretinPTNCI-GLOSSCDR0000523453
  • BexarotenePTNCI
DEFINITION
  • A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)NCI
code
  • C1635
sameAs
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