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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Plevitrexed
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Plevitrexed
UMLS_CUI
  • C0299046
CAS_Registry
  • 153537-73-6
FDA_UNII_Code
  • L9P2881C3H
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 38264
PDQ_Closed_Trial_Search_ID
  • 38264
Chemical_Formula
  • C26H25FN8O4
Legacy_Concept_Name
  • ZD9331
FULL_SYN
  • PlevitrexedPTNCI
  • (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic AcidPTDCP50641
  • (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic AcidSNNCI
  • ZD9331CNNCI
  • VamidexSYNCI
  • VamydexSYNCI
  • BGC 9331CNNCI
  • PLEVITREXEDPTFDAL9P2881C3H
DEFINITION
  • An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential antineoplastic activity. Plevitrexed is transported into the cell via the physiological reduced folate carrier (RFC) system. Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, which may result in DNA synthesis inhibition and apoptosis.NCI
code
  • C1629
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