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AttributesValues
rdf:type
rdfs:label
  • Alpha-Fetoprotein
equivalentClass
OMIM_Number
  • 104150
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Alpha-Fetoprotein
UMLS_CUI
  • C0002210
ALT_DEFINITION
  • A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor.NCI-GLOSS
Legacy_Concept_Name
  • Alpha-Fetoprotein
FULL_SYN
  • AFPSYNCI
  • Alpha-FetoproteinSYNCITCGA
  • AFPPTNCI-GLOSSCDR0000044861
  • alpha-fetoproteinPTNCI-GLOSSCDR0000046208
  • alpha-FetoproteinPTDCP05864
  • Alpha-FetoproteinPTNCI
  • Alpha-FetoglobulinSYNCI
  • Alpha-1-FetoproteinSYNCI
DEFINITION
  • Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)NCI
code
  • C16278
sameAs
http://linked.open...y/mesh/hasConcept
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