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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Elinafide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Elinafide
UMLS_CUI
  • C0294830
CAS_Registry
  • 162706-37-8
FDA_UNII_Code
  • HL580335SI
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that kills cancer cells by affecting DNA synthesis.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42578
PDQ_Closed_Trial_Search_ID
  • 42578
Chemical_Formula
  • C31H28N4O4
Legacy_Concept_Name
  • LU_79553
FULL_SYN
  • N,N'-(Trimethylenebis(iminoethylene))dinaphthalimideSNNCI
  • ELINAFIDEPTFDAHL580335SI
  • LU 79553PTNCI-GLOSSCDR0000045517
  • LU 79553CNNCI
  • LU-79553CNNCI
  • ElinafidePTNCI
DEFINITION
  • A symmetrical dimeric bis-naphthalimide compound and a topoisomerase II inhibitor with antineoplastic activity. Elinafide contains two neutral chromophores joined by a cationic linker and is capable of bis-intercalation at the TpG and CpA steps of the DNA hexanucleotide. Intercalation inhibits topoisomerase II activity and causing DNA stand breakage, thereby leads to inhibition of DNA, RNA, and protein synthesis.NCI
code
  • C1615
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