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AttributesValues
rdf:type
rdfs:label
  • Anastrozole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Anastrozole
NSC_Code
  • 719344
UMLS_CUI
  • C0290883
CAS_Registry
  • 120511-73-1
Accepted_Therapeutic_Use_For
  • Hormone Receptor-Positive Early Breast cancer
In_Clinical_Trial_For
  • Breast cancer
FDA_UNII_Code
  • 2Z07MYW1AZ
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42540
PDQ_Closed_Trial_Search_ID
  • 42540
Chemical_Formula
  • C17H19N5
Legacy_Concept_Name
  • Anastrozole
CHEBI_ID
  • CHEBI:2704
FULL_SYN
  • AnastrozoleSYDTPNSC0719344
  • AnastrozolePTNCI
  • Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrileSNNCI
  • anastrozolePTNCI-GLOSSCDR0000045504
  • AnastrozolePTDCP20054
  • ICI D1033SYDTPNSC0719344
  • 2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)SNNCI
  • ZD-1033CNNCI
  • ArimidexBRNCI
  • ICI-D1033CNNCI
  • ANASTROZOLEPTFDA2Z07MYW1AZ
DEFINITION
  • A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)NCI
code
  • C1607
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