About: Loperamide Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Loperamide Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Loperamide Hydrochloride
UMLS_CUI
  • C0282221
CAS_Registry
  • 34552-83-5
FDA_UNII_Code
  • 77TI35393C
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat diarrhea. Imodium slows the movement of the muscles in the small intestine to allow more water to be taken out of the feces (waste matter) and more nutrients to be absorbed.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41911
PDQ_Closed_Trial_Search_ID
  • 41911
Chemical_Formula
  • C29H33ClN2O2.HCl
Legacy_Concept_Name
  • Loperamide_Hydrochloride
FULL_SYN
  • Imodium A-DBRNCI
  • loperamide hydrochloridePTNCI-GLOSSCDR0000045756
  • Loperamide HydrochloridePTNCI
  • LOPERAMIDE HYDROCHLORIDEPTFDA77TI35393C
  • ImodiumPTNCI-GLOSSCDR0000579912
DEFINITION
  • The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects.NCI
code
  • C1584
sameAs
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