About: Nolatrexed Dihydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nolatrexed Dihydrochloride
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nolatrexed Dihydrochloride
UMLS_CUI
  • C0796399
CAS_Registry
  • 152946-68-4
Accepted_Therapeutic_Use_For
  • Hepatocellular carcinoma
In_Clinical_Trial_For
  • Hepatocellular cancer
FDA_UNII_Code
  • 1XA69O733O
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42223
PDQ_Closed_Trial_Search_ID
  • 42223
Chemical_Formula
  • C14H12N4OS.2ClH
Legacy_Concept_Name
  • Nolatrexed
FULL_SYN
  • nolatrexedPTNCI-GLOSSCDR0000046126
  • 3,4-Dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline DihydrochlorideSNNCI
  • Nolatrexed HydrochlorideSYNCI
  • AG337PTNCI-GLOSSCDR0000044442
  • Nolatrexed DihydrochloridePTNCI
  • AG-337CNNCI
  • NOLATREXED DIHYDROCHLORIDEPTFDA1XA69O733O
  • ThymitaqPTNCI-GLOSSCDR0000413959
  • ThymitaqBRNCI
DEFINITION
  • The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.NCI
code
  • C1577
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