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AttributesValues
rdf:type
rdfs:label
  • Alitretinoin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alitretinoin
NSC_Code
  • 659772
UMLS_CUI
  • C0281666
CAS_Registry
  • 5300-03-8
Accepted_Therapeutic_Use_For
  • Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi sarcoma
FDA_UNII_Code
  • 1UA8E65KDZ
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42147
PDQ_Closed_Trial_Search_ID
  • 42147
Chemical_Formula
  • C20H28O2
Legacy_Concept_Name
  • Alitretinoin
CHEBI_ID
  • CHEBI:50648
FULL_SYN
  • 9-Cis-Retinoic AcidSYDTPNSC0659772
  • ALITRETINOINPTFDA1UA8E65KDZ
  • AlitretinoinPTNCI
  • 9-cis retinoic acidPTNCI-GLOSSCDR0000045583
  • AlitretinoinPTDCP01346
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic AcidSNNCI
  • 9-cRAABNCI
  • LGD1057CNNCI
  • Retinoicacid-9-cisSYNCI
  • 9-cis Retinoic AcidSYNCI
  • 9-cis-Retinoic AcidSYNCI
  • ALRT1057CNNCI
  • 9-cis-RAABNCI
  • PanretinBRNCI
  • PanrexinFBNCI
  • PanretynFBNCI
DEFINITION
  • An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.NCI
code
  • C1574
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