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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Safingol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Lipid
  • Pharmacologic Substance
Preferred_Name
  • Safingol
NSC_Code
  • 714503
UMLS_CUI
  • C0281466
CAS_Registry
  • 15639-50-6
FDA_UNII_Code
  • OWA98U788S
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41910
PDQ_Closed_Trial_Search_ID
  • 41910
Chemical_Formula
  • C18H39NO2
Legacy_Concept_Name
  • Dihydrosphingosine
FULL_SYN
  • L-(-)-threo-SphingnineSYNCI
  • (2S,3S)-2-Amino-1,3-OctadecanediolSNNCI
  • SphinganineSYNCI
  • L-threo-2-Amino-1,3-octadecanediolSYNCI
  • L-threo-dihydrosphingosinePTNCI-GLOSSCDR0000513024
  • L-Threo-DihydrosphingosineSNNCI
  • L-Threo-DihydrosphingosineSYNCI
  • SAFINGOLPTFDAOWA98U788S
  • SafingolSYDTPNSC0714503
  • safingolPTNCI-GLOSSCDR0000386229
  • SafingolPTNCI
  • KynacyteBRNCI
  • SPC-100270CNNCI
  • SafingolPTDCP20441
DEFINITION
  • A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.NCI
code
  • C1568
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