About: Liposomal Amphotericin B     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Liposomal Amphotericin B
rdfs:subClassOf
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Liposomal Amphotericin B
UMLS_CUI
  • C1145701
PDQ_Open_Trial_Search_ID
  • 43048
PDQ_Closed_Trial_Search_ID
  • 43048
Legacy_Concept_Name
  • Amphotericin_B-Lipid_Complex
FULL_SYN
  • Amphotericin B LiposomalSYNCI
  • Liposomal Amphotericin BPTNCI
  • Liposomal Amphotericin BSYNCI
  • L-AMBABNCI
  • Amphotericin B-Lipid ComplexSYNCI
  • Lipid Complex, Amphotericin BSYNCI
  • AbelcetBRNCI
  • AmBisomeSYNCI
DEFINITION
  • A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B produced by the bacterium Streptomyces nodosus with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.NCI
code
  • C1566
sameAs
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