About: Pemetrexed Disodium

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About: Pemetrexed Disodium Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pemetrexed Disodium
rdfs:subClassOf	Thymidylate Synthase Inhibitor Folate Antagonist
Has_Free_Acid_Or_Base_Form	PEMETREXED
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Pemetrexed Disodium
NSC_Code	698037
UMLS_CUI	C1101816
CAS_Registry	150399-23-8
Accepted_Therapeutic_Use_For	Malignant pleural mesothelioma; Non-small cell lung cancer
FDA_UNII_Code	2PKU919BA9
Contributing_Source	FDA
ALT_DEFINITION	A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42328
PDQ_Closed_Trial_Search_ID	42328
Chemical_Formula	C20H19N5O6.2Na
Legacy_Concept_Name	Pemetrexed
CHEBI_ID	CHEBI:63722
FULL_SYN	N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium SaltPTDCP50621 N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium SaltSNNCI pemetrexed disodiumPTNCI-GLOSSCDR0000045456 AlimtaPTNCI-GLOSSCDR0000410734 LY231514PTNCI-GLOSSCDR0000044358 AlimtaBRNCI LY231514CNNCI Pemetrexed DisodiumPTNCI PEMETREXED DISODIUMPTFDA2PKU919BA9
DEFINITION	The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI
code	C1533
sameAs	Pemetrexed Disodium
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0407271
is someValuesFrom of	nodeID://b657304 nodeID://b660462 nodeID://b660524 nodeID://b676702 nodeID://b684374 nodeID://b684387 nodeID://b702236
is Has_Salt_Form of	PEMETREXED
is sameAs of	Pemetrexed Disodium

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