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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Troglitazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Troglitazone
UMLS_CUI
  • C0245514
CAS_Registry
  • 97322-87-7
FDA_UNII_Code
  • I66ZZ0ZN0E
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 42706
PDQ_Closed_Trial_Search_ID
  • 42706
Legacy_Concept_Name
  • Troglitazone
CHEBI_ID
  • CHEBI:9753
FULL_SYN
  • TROGLITAZONEPTFDAI66ZZ0ZN0E
  • TroglitazonePTNCI
  • TroglitazonePTDCP09341
  • CI-991CNNCI
  • CS-045CNNCI
  • PrelayBRNCI
  • RezulinBRNCI
  • RomozinBRNCI
  • 5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl-2,4-thiazolidinedioneSNNCI
  • 5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedioneSNNCI
DEFINITION
  • An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)NCI
code
  • C1522
sameAs
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