About: Roquinimex     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Roquinimex
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Roquinimex
UMLS_CUI
  • C0244748
CAS_Registry
  • 84088-42-6
FDA_UNII_Code
  • 372T2944C0
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41410
PDQ_Closed_Trial_Search_ID
  • 41410
Chemical_Formula
  • C18H16N2O3
Legacy_Concept_Name
  • Roquinimex
FULL_SYN
  • RoquinimexPTNCI
  • 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamideSNNCI
  • 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamidePTDCP09087
  • 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilideSNNCI
  • FCF 89CNNCI
  • LS 2616CNNCI
  • ROQUINIMEXPTFDA372T2944C0
  • LinomideBRNCI
  • N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamideSNNCI
DEFINITION
  • A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04)NCI
code
  • C1519
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