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AttributesValues
rdf:type
rdfs:label
  • Raloxifene
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Raloxifene
UMLS_CUI
  • C0244404
CAS_Registry
  • 84449-90-1
Accepted_Therapeutic_Use_For
  • Breast cancer; Cardiovascular Disease prophylaxis; Osteoporosis
In_Clinical_Trial_For
  • Endometriosis; Pelvic Pain
FDA_UNII_Code
  • YX9162EO3I
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of the disease or who have osteoporosis. It is also used to prevent and treat osteoporosis in postmenopausal women. It is also being studied in the prevention of breast cancer in certain premenopausal women and in the prevention and treatment of other conditions. Raloxifene blocks the effects of the hormone estrogen in the breast and increases the amount of calcium in bone. It is a type of selective estrogen receptor modulator (SERM).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43109
PDQ_Closed_Trial_Search_ID
  • 43109
Chemical_Formula
  • C28H27NO4S
Legacy_Concept_Name
  • Raloxifene
CHEBI_ID
  • CHEBI:8772
FULL_SYN
  • [6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanoneSNNCI
  • raloxifenePTNCI-GLOSSCDR0000046046
  • RALOXIFENEPTFDAYX9162EO3I
  • LY 139481CNNCI
  • KeoxifeneSYNCI
  • RaloxifenePTDCP308
  • RaloxifenePTNCI
DEFINITION
  • A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI04)NCI
code
  • C1518
sameAs
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