About: Aldesleukin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aldesleukin
equivalentClass
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Aldesleukin
UMLS_CUI
  • C0218986
CAS_Registry
  • 110942-02-4
FDA_UNII_Code
  • M89N0Q7EQR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat some types of cancer. It is a form of interleukin-2, a cytokine made by leukocytes (white blood cells), that is made in the laboratory. Aldesleukin increases the activity and growth of white blood cells called T lymphocytes and B lymphocytes. It is a type of biological response modifier.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39756
PDQ_Closed_Trial_Search_ID
  • 39756
Legacy_Concept_Name
  • Aldesleukin
FULL_SYN
  • Recombinant Human IL-2SYNCI
  • r-serHuIL-2ABNCI
  • AldesleukinPTNCI
  • recombinant human interleukin-2PTNCI-GLOSSCDR0000579605
  • aldesleukinPTNCI-GLOSSCDR0000046679
  • ALDESLEUKINPTFDAM89N0Q7EQR
  • 125-L-Serine-2-133-interleukin 2SYNCI
  • Recombinant Human Interleukin-2SYNCI
  • ProleukinBRNCI
  • ProleukinPTNCI-GLOSSCDR0000579601
DEFINITION
  • A recombinant analog of the endogenous cytokine interleukin-2 (IL-2) with immunoregulatory and antineoplastic activities. Aldesleukin binds to and activates the IL-2 receptor, followed by heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains; activation of the tyrosine kinase Jak3; and phosphorylation of tyrosine residues on the IL-2R beta chain, resulting in an activated receptor complex. Various cytoplasmic signaling molecules are recruited to the activated receptor complex and become substrates for regulatory enzymes that are associated with the receptor complex. This agent enhances lymphocyte mitogenesis; stimulates long-term growth of human IL-2 dependent cell lines; enhances lymphocyte cytotoxicity; induces lymphokine-activated killer (LAK) cell and natural killer (NK) cell activities; and induces expression of interferon-gamma. Aldesleukin may induce T cell-mediated tumor regression in some tumor types.NCI
code
  • C1498
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software