About: C57BL/6 Mouse

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Attributes	Values
rdf:type	Class
rdfs:label	C57BL/6 Mouse
rdfs:subClassOf	Inbred Mouse Strains
Concept_In_Subset	Clinical Data Interchange Standards Consortium Terminology CDISC SEND Terminology CDISC SEND Laboratory Animal Strain Terminology
Semantic_Type	Mammal
Display_Name	C57BL/6 Mouse
Preferred_Name	C57BL/6 Mouse
UMLS_CUI	C1521751
Contributing_Source	CDISC
ALT_DEFINITION	Derived by Little (1921) from A Lathrop stocks and separated out before 1937, the C57BL/6 mouse has a black coat and carries a Y chromosome of Asian Mus musculus origin and a LINE-1 element from Mus spretus. Substrain C57BL/6 differs from other substrains at multiple loci, including H9, Igh2 and Lv, on chromosome 4. This mouse model is prone to the development of fatty lesions in the aorta similar to atheromatous plaque in humans, as well as hyperglycemia, hyperinsulinemia, hypercholesterolemia and non-insulin-dependent diabetes mellitus in response to a high fat diet.CDISC
MGI_Accession_ID	MGI:2159769
Legacy_Concept_Name	C57BL_6
FULL_SYN	C57BL/6 MousePTNCI B6SYNCI C57BL/6PTJAX C57BL/6PTCDISC
DEFINITION	Derived by Little (1921) from A Lathrop stocks and separated out before 1937, the C57BL/6 mouse has a black coat and is one of the most widely used inbred strains. It accounts for 14% of all mouse inbred strain laboratory usage. The strain carries a Y chromosome of Asian Mus musculus origin and a LINE-1 element from Mus spretus, suggesting that up to 6.5% of the genome is Mus spretus in origin. Substrain C57BL/6 differs from other substrains at multiple loci, including H9, Igh2 and Lv, on chromosome 4. This mouse model is prone to the development of fatty lesions in the aorta similar to atheromatous plaque in humans, as well as hyperglycemia, hyperinsulinemia, hypercholesterolemia and non-insulin-dependent diabetes mellitus in response to a high fat diet. The C57BL/6 strain exhibits good reproductive performance and hermaphroditism in this substrain has been shown to occur.NCI
code	C14424

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